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Tuesday 11 December |
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| 8:20 - 8:30 |
Jonathan Crowston, Franz Grus & Keith Martin |
Welcome and Introduction |
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Session I: Bioenergetics |
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Moderators: Pete Williams & Jonathan Crowston |
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| 8:30 - 8:50 |
Peter van Wijngaarden |
Bioenergetics of the optic nerve |
| 8:50 - 9:10 |
Pete WIlliams |
Targeting neuronal mitochondria for neuroprotection in glaucoma |
| 9:10 - 9:30 |
Grace Zhai |
A balance of NAD+ metabolism and proteostasis in NMNAT_mediated neuroprotection |
| 9:30 - 9:50 |
Guy Lenaers |
Genetic, physiopathology and metabolic analyses of dominant optic neuropathies, towards defining future therapies |
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Morning Tea |
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Session II: Inner Retina and Optic Nerve Regeneration |
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Moderators: Bryan Jones & Keith Martin |
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| 10:30 - 10:50 |
Richard Eva |
Enabling optic nerve regerneration through the mobilisation of axon growth machinery |
| 10:50 - 11:10 |
Lieve Moons |
Inflammatory stimulation as fuel for axon regeneration: elucidating underlying cellular and molecular players |
| 11:10 - 11:30 |
Michel Cayouette |
Regulating intraneuronal Tau levels in retinal ganglion cells |
| 11:30 - 11:40 |
Tasneem Khatib |
Axon transport and regeneration following glaucomatous injury |
| 11:40 - 11:50 |
Rachel Evans |
Manipulation of the PI3-kinase pathway to promote RGC axon regeneration in vivo using the optic nerve crush model |
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Lunch Break |
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Session III: Autophagy |
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Moderators: Katharina Bell & Christian Behl |
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| 17:30 - 17:50 |
Albrecht Clement |
DNAJC13, a Parkinson’s disease-associated gene, modulates autophagy |
| 17:50 - 18:10 |
Jochen Weishaupt |
Molecular genetics of the ALS- and glaucoma-associated TBK1 |
| 18:10 - 18:30 |
Christian Behl |
Autophagy as adaptive process in neuronal cells |
| 18:30 - 18:50 |
Christian Behrends |
Identifying machinery and cargo of selective autophagy |
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Wednesday 12 December |
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Session IV: Neuroinflammation |
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Moderators: Franz Grus & Miriam Kolko |
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| 8:30 - 8:50 |
Miriam Kolko |
Systemic implications of glaucomatous optic neuropathy |
| 8:50 - 9:10 |
Alyson Fournier |
14-3-3 proteins and CNS regeneration |
| 9:10 - 9:30 |
Katharina Bell |
14-3-3 proteins in glaucoma |
| 9:30 - 9:40 |
Carsten Schmelter |
CDR peptides in glaucoma |
| 9:40 - 9:50 |
Vanessa Beutgen |
Analysis of autoantibodies in glaucoma subtypes |
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Morning Tea |
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Session V: Electirical Activity to Neuronal Biointerfaces |
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Moderators: Manohar Bance & Damiano Barone |
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| 10:30 - 10:50 |
Manohar Bance |
Machine-neural interfaces in auditory disorders |
| 10:50 - 11:10 |
Damiano Barone |
Restoring lost function: chellenges and prospects in neural interface technology |
| 11:10 - 11:30 |
Alejandro Carnicer |
Mechano-biology challenges in neuro-prosthetics and peripheral nerve injury |
| 11:30 - 11:40 |
Christian van Oterendorp |
Influence of polyacrylamide gel substrates on primary retinal ganglion cell culture |
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Lunch Break |
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Session VI: Innovation and Translation |
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Moderators: Darren Kelly |
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| 17:30 - 17:50 |
Leonard Levin |
Challenges to translating treatments for optic neuropathies |
| 17:50 - 18:10 |
Darren Kelly |
Molecules to medicine: lessons from developing antifibrosis drugs for eye disease |
| 18:10 - 18:30 |
David Mackey |
Glaucoma genetics - what it tells us about disease pathogenesis |
| 18:30 - 18:40 |
Jessica Tang |
The short-term effect of intraocular pressure reduction on the photopic negative response in glaucoma |
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Thursday 13 December |
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Session VII: Glial-Neural Interactions |
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Moderators: Thora Karadottir & Andras Lakatos |
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| 8:30 - 8:50 |
Andras Lakatos |
Neuronal help-me signals in astrocyte-mediated repair and neurodegeneration |
| 8:50 - 9:10 |
Tom Johnson |
Retinal integration of transplanted stem cells as a fundamental step towards RGC replacement therapy |
| 9:10 - 9:30 |
Aiman Saab |
Studying axon-glial signaling and axonal energy metabolism in the optic nerve |
| 9:30 - 9:50 |
Sarah Förster |
Functional heterogeneity of oligodendrocytes in the CNS |
| 9:50 - 10:00 |
Seungsoo Rho |
Chronic ocular hypertensive rat model using various microbeads |
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Morning Tea |
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Session VIII: Sick Ganglion Cells |
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Moderators: Leonard Levin & Elena Veccino |
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| 10:30 - 10:50 |
Claire Mitchell |
Linking IOP elevation to microglial cell activation through ATP |
| 10:50 - 11:10 |
Elena Veccino |
How Müller glía help RGCs |
| 11:10 - 11:30 |
Grace Lidgerwood |
Engineering a human reitna in a dish using patient IPSC -derived retinal cells |
| 11:30 - 11:50 |
Vicki Chysostomou |
Exercise promotes RGC functional recovery |
| 11:50 - 12:00 |
Daun Jeong |
Effect of refractive error on the physiologic thinning rate of retinal nerve fiber layer in healthy eyes |
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Lunch Break |
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Session IX: Synaptic Remodelling |
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Moderators: James Morgan |
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| 17:30 - 17:50 |
James Morgan |
Dendritic remodelling in human glaucoma |
| 17:50 - 18:10 |
Bryan Jones |
Connectomics frameworks for ganglion cell connectivity |
| 18:10 - 18:20 |
Yuhong Dong |
Preliminary observations from a pilot study on the effects of SRG003 in spontaneous idiopathic Optic Atrophy in the rhesus monkey |
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Keith, Franz and Jonathan |
Brief wrap up and solicit suggestions for next Obergurgl 2019 |
